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 Intraperitoneal Bevacizumab for Control of Malignant Ascites

Malignant ascites are an accumulation of fluid within the peritoneal cavity caused by tumors or cancer. It is a life-threatening condition with a poor prognosis and it is difficult to treat, making it a major clinical challenge. Intraperitoneal bevacizumab is a new treatment option that is of benefit in the control of malignant ascites.

Role of this effects

Bevacizumab Injection is a monoclonal antibody which works by blocking the effects of vascular endothelial growth factor (VEGF). VEGF is a cytokine involved in angiogenesis which is crucial for the survival and growth of many solid tumor types. When VEGF is blocked, newly formed tumor vessels can no longer be supported, resulting in disruption of tumor angiogenesis or even tumor cell death.

Why bevacizumab is preferred

Before bevacizumab, other chemotherapeutic agents and drugs such as octreotide and spironolactone were used to reduce the amount of ascites fluid. However, these drugs can cause adverse effects such as nausea, vomiting, or abdominal pain. Bevacizumab is a viable alternative for patients who cannot tolerate the side effects of other drugs.

Results from clinical trials

In clinical trials, bevacizumab was administered intraperitoneally combined with oral chemotherapy to treat malignant ascites. The results indicated that bevacizumab significantly improved the response and outcome of treatment, with most patients showing a decrease in ascites fluid volume, improved quality of life, and longer survival times.

Advantageous zone of its improvement

The use of bevacizumab for the control of malignant ascites appears to be both safe and effective. Studies have shown that it is associated with minimal side effects compared to other treatment options, and it is well tolerated in most cases with no serious adverse effects reported.

Insight into bevacizumab

Bevacizumab (Avastin) is a monoclonal antibody that has revolutionized the treatment of angiogenesis, a process by which new blood vessels are formed. Angiogenesis is a crucial part of many diseases, from wound healing to cancer. Bevacizumab has been used successfully to target and inhibit the growth of abnormal vascularization associated with disease, slowing the progression of angiogenesis and making it possible to reduce symptoms and improve quality of life.

The specific action of bevacizumab

Bevacizumab is a recombinant humanized monoclonal antibody, which means that it is a laboratory-created type of antibody grown using genetically engineered cells. Its specific target is the vascular endothelial growth factor (VEGF), which is responsible for angiogenesis. By binding to VEGF, bevacizumab is able to block the formation of new blood vessels, leading to a decrease in the disease’s progression.

Approved for its use

Bevacizumab has been approved by the FDA for the treatment of age-related macular degeneration (AMD). AMD causes the gradual loss of central and peripheral vision due to leakage from newly formed blood vessels and the growth of scar tissue. Bevacizumab is administered as an intravitreal injection to reduce levels of VEGF and slow the growth of abnormal new vessels, reducing the risk of further vision loss.

Bevacizumab price

Bevacizumab 400mg is an injectable medication used to treat certain types of cancer. It is a biologic, meaning it is made from living organisms and the drug differs from person to person. The price of Bevacizumab 400mg Price depends on a variety of factors, such as the dosage you need and the supplier you purchase it from. Thankfully, many insurance plans offer coverage for this medication, so be sure to check with your provider before committing to buying this potentially costly treatment.


In conclusion, intraperitoneal bevacizumab is an effective, safe, and well-tolerated treatment option for the control of malignant ascites. It has been shown to improve the response and prognosis of the disease and has fewer side effects than other drugs currently used for the treatment. As such, bevacizumab should be considered for patients with malignant ascites.

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